DuPont™ Liveo™ Topical Formulations

Expertise to support you in your topical formulations, from concept to scale-up

From formulation concept development to lab-scale manufacturing through commercial-scale manufacturing – and for a variety of formulations and types, from anhydrous to hydroalcoholic – DuPont™ Liveo™ can help you develop formulations that address today’s healthcare challenges, provide efficacious drug delivery and encourage patient compliance.

When you choose DuPont™ Liveo™ Healthcare Solutions, you benefit from a depth of knowledge, experience and processes that can help you bring new formulations to market:

Innovative silicone excipients & blends to enhance your formulations

DuPont™ Liveo™ offers a wide range of silicone excipients and customized blends to address a variety of customer-specific needs in a wide range of consumer healthcare and pharmaceutical applications and dermatological therapies.

Formulations with silicone material offer various dosage forms and textures; they also provide efficient drug delivery, proven aesthetics, functional film characteristics and long-lasting effects that are well-adapted for different skin diseases. In terms of patients’ compliance with treatment, the optimized efficiency of drug delivery and the behavior of silicone-containing formulations on skin can lead to better perceived efficacy and a more pleasant sensory feel, encouraging greater compliance.

Topical Formulation concepts formanagement of common indications

We help optimize the efficacy and the texture of formulations for scar treatment, advanced wound care, ostomy and incontinence, dry skin conditions and local pain management. Selected indications and formulation concepts are outlined below. These concepts aim to illustrate possible uses of the DuPont™ Liveo™ topical range and are offered as examples of “go-to-formulations” ready to scale in manufacturing following customer’s evaluation and testing, or can be further customized to meet specific customer requirements.

CAUTION: Use is subject to DuPont Medical Application Policy and standard terms of sale. Customer is responsible for final product material selection, design choices, and regulatory registrations/compliance in jurisdictions of manufacturing and sale of final products. All warranties for DuPont material, beyond meeting current sales Specification at the time of shipment, are disclaimed unless explicitly negotiated in a written agreement executed by duly authorized representatives of the parties.

SCAR MANAGEMENT

Non-invasive topical treatment products – including DuPont™ Liveo™ silicone materials can provide first-line therapy scar management to treat all types of scars, such as keloid scars, contracture scars, hypertrophic scars, scars from burns and atrophic scars.

Gel formulations

____

Topical gels are one of the most popular forms for scar management. They are easy to apply and cosmetically acceptable.

SiCar Gel SC3013: This breathable anhydrous gel formulation concept is smooth, non-greasy and easy to spread on skin. The comfortable, pleasant feel and ease of use of such a silicone-based formulation can improve patient compliance.

Substantive SiCar Gel SC3022: This substantive, wash-off-resistant, non-occlusive anhydrous gel formulation concept offers skin protectancy. It improves spreadability and allows for skin protectancy claims in accordance with the monograph.

Mattifying SiCar Gel SC3014: This anhydrous gel formulation concept is non-occlusive and substantive and offers skin protectancy with a mattifying effect and a pleasant, smooth, light, non-greasy feel. It improves spreadability and allows for skin protectancy claims in accordance with the monograph.

Protective Scar Gel SC3019: This easy-to-spread anhydrous gel formulation concept is breathable, non-occlusive and substantive and offers skin protectancy and wash-off resistance.

Balancing Scar Gel SC3020: This smooth anhydrous gel formulation concept offers skin protectancy and wash-off resistance. It is non-greasy and easy to spread, which can improve patient comfort.

Refreshing Scar Gel SC3021: This is a smooth, non-greasy, non-tacky anhydrous gel formulation concept with a light feel. It offers substantivity and wash-off resistance. The ease of spreading, mattifying effect and pleasant feel may improve patient compliance.

UV SiCar Gel SC3023: This easy-to-spread, non-tacky anhydrous gel formulation concept contains sun filters and provides a mattifying effect on skin. It is a substantive, wash-off-resistant anhydrous gel that leaves a skin protectant film on skin and provides a smooth, pleasant feel.

Cream formulations

____

Topical creams are used for their moisturizing effect and allow the addition of hydrophobic active which helps to reduce the scar.

Moisturizing SiCar Cream SC3026: This breathable oil-in-water cream formulation concept is smooth and non-greasy, and provides a matte effect on skin. This emulsion combine silicone, glycerin and Centella asiatica for moisturization and sensorial properties.

MOISTURE-ASSOCIATED SKIN DAMAGE (MASD)

Barrier formulations:Silicone-based formulations designed to protect skin from prolonged exposure to moisture, such as wound exudate, urinary and fecal incontinence, excessive sweat, and other bodily fluids that can cause skin damage.

Barrier Spray formulations

____

Silicone-based formulations designed to protect skin from prolonged exposure to moisture.

Barrier Spray SB3038
Barrier Spray SB3040
Barrier Spray SB3041
Barrier Spray SB3042

Barrier Cream formulations

____

Silicone-based formulations designed to protect skin from prolonged exposure to moisture.

Barrier Cream SB3032
Barrier Cream SB3037

OSTOMY

Gentle, effective, pleasant-feeling and easy to use ostomy care products encourage patients to take better care of the skin around their stoma. When properly treated, skin stays healthier and patients experience less discomfort.

Cream formulations

____

Help prevent and protect against potential skin damage

Ostomy Breathable Barrier Cream OS3011: This water-in-oil emulsion formulation concept is breathable and substantive on skin while offering wash-off resistance and a smooth, non-greasy feel. The ease of spreading is helpful for patients during application. It is easy to formulate and allows for cold processing.

Ostomy Water-Resistant Barrier Cream OS3012: This oil-in-water emulsion formulation concept provides long-lasting wear on the skin, as well as wash-off resistance. It leaves a smooth, non-greasy, non-tacky, matte film on the skin.

Spray formulations

____

Protect against potential skin damage without affecting the adhesion of the baseplate.

Ostomy Barrier Spray OS3010: This spray formulation concept provides a smooth feel on skin and delivers a wash-off resistant substantive film. The alcohol-free formulation has low odor compared to an alcohol-based competitive alternative. It contains volatile solvents, allowing quick evaporation and drying time.

Washable barrier Spray OS 3024: This spray formulation concept provides a smooth feel on skin and delivers a substantive, washable film. The alcohol-free formulation has low odor compared to an alcohol-based competitive alternative.

ACNE

Non-comedogenic and non-acnegenic silicone materials from DuPont™ Liveo™ are ingredients of choice for acne management.

Cream formulations

____

Provide a richer texture to help on dry skin. The presence of water phase in the formulation helps to disperse hydrophilic active ingredients such as salicylic acid and benzoic acid.

Acne Matte Serum AC3016: This cream is semi-occlusive on skin and offers a mattifying effect and smooth, light, pleasant feel on skin. It is a suitable matrix for drug delivery of hydrophilic active, such as salicylic acid.

DRY SKIN

Skin that lacks adequate moisture is considered to be dry. To treat dry skin, a formulation should provide hydration and ideally will leave a smooth, pleasant film on the skin.

Cream formulations

____

Creams are designed to prevent dry, cracked skin while keeping it supple and moisturized.

Moisturizing Cream DS3015: This hydrating cream leaves a mattifying, non-occlusive film on the skin. It is an emulsion that combines silicone and glycerin for moisturization and an enhanced sensory experience – including a smooth, pleasant feel – and it maintains similar hydration versus a formulation without silicone. It is an easy-to-formulate emulsion allowing for cold processing.

Moisturizing W/O Emulsion DS3030: This hydrating, breathable cream is an emulsion that combines silicone and glycerin for moisturization and enhanced sensory experience – including a smooth, pleasant feel – and it maintains similar hydration versus a formulation without silicone. It is an easy-to-formulate emulsion allowing for cold processing.

Water-in-oil emulsion with variable levels of Urea DS3035: These gentle, hydrating water-in-oil creams combine a blend silicone film former with Urea to deliver advanced exfoliation and moisturization for dry, cracked skin. Formulated for daily skin resilience and renewal, these formulations provide relief from itchy skin, eczema, and psoriasis.

Oil-in-water emulsion with variable levels of Urea DS3036: These hydrating oil-in-water creams combine blend of silicone film former with Urea to deliver gentle, effective care for dry skin. Formulated to soften and moisturize rough, calloused, and cracked skin, these creams support daily skin resilience and intensive skin renewal.

ATOPIC DERMATITIS

Eczema is a chronic, non-contagious inflammatory skin disease that affects 15 to 25% of people worldwide and is becoming increasingly frequent. Pleasant feeling creams may increase patient compliance.

Cream formulations

____

Silky feel cream that may increase patient compliance, making them ingredients of choice for management of atopic dermatitis and eczema.

Moisturizing AtopiSmooth Cream AD3031: This therapeutic moisturizing cream for the body has a semi-occlusive property that offers a non-tacky, pleasant feel on the skin.

PSORIASIS

Psoriasis a skin disorder characterized by red, flaky, scaly skin and white, dead skin cell buildup – affects 125 million people worldwide . Of the patients treated topically for psoriasis, 70% are non-compliant. A comfortable, smooth, light, pleasant feel of silicone-based emulsions can improve patient compliance.

Cream formulations

____

Creams are commonly used to treat mild to moderate psoriasis in most areas of the body. Creams are easy to use.

Psoriasis Light Cream PS3017: This cream is a suitable matrix for drug delivery of hydrophobic active, such as betamethasone dipropionate (BDP). This emulsion is smooth and semi-occlusive on the skin. The ease of use and the comfortable, smooth, light, pleasant feel of such a silicone-based emulsion can improve patient compliance.

Psoriasis Easy-to-Spread Cream PS3018: This cream is a suitable matrix for drug delivery of hydrophobic active, such as betamethasone dipropionate (BDP). This emulsion is easy to spread, smooth, non-greasy and semi-occlusive on skin and has a pleasant feel.

FUNGAL INFECTIONS

Antifungal medicines (“antifungals”) – available in fungicidal (kills fungus) or fungistatic (slows growth of fungus) forms – are used to treat fungal infections that commonly occur on the skin including several types of fungal skin infections, ranging from ringworm to dandruff (seborrheic dermatitis) to fingernail infections and toenail fungus to vaginal yeast infections and more.

Liquid formulations

____

Anti-fungal sprays are often preferred for treating infections because they're easy to apply and may have better drying time.

Protective Antifungal Foot Spray AF3025: This protective, breathable spray for feet has a pleasant feel and scent linked to the presence of essential oils known for antibacterial and antifungal properties.

DRUG DELIVERY FOR A VARIETY OF INDICATIONS

Cream formulations

Pure and Simple 1710: This efficient, semi-occlusive cream formulation concept is a suitable matrix for drug delivery of hydrophilic active, such as caffeine. This oil-in-water emulsion is smooth, comfortable, substantive and moisturizing while protecting the skin.